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Substantial methodological differences between studies complicate matters further, with some studies controlling for medication whereas others do not (Romano et al., 2021)

These symptoms can include: Unexplained rashes Muscle or joint pain Low-grade fever Hair loss Enlarged lymph nodes Brain fog or cognitive difficulties Raynauds phenomenon (fingers or toes that turn white or blue in response to cold or stress) Dry eyes and mouth Photosensitivity (unusual reaction to sunlight) Its important to note that the ANA test is primarily a screening tool

In addition, although numerous strategies for managing these AEs have been described, their application in clinical practice continues to evolve